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Sei Iwai


 


 

Sei Iwai, MD, FACC
Professor of Medicine
Director, Complex Arrhythmia Ablation Program
Director, Clinical Cardiac Electrophysiology Fellowship Program

Division of Cardiovascular Medicine
SUNY-Stony Brook Health Sciences Center T16-080
Stony Brook, NY 11794
Phone: 631-444-3575
Fax: 631-444-1054
E-mail: sei.iwai@stonybrook.edu

EDUCATION AND TRAINING

  • BA, Harvard College, Cambridge, MA, 1990
  • MD, College of Physicians and Surgeons, Columbia University, New York, NY, 1994
  • Resident in Internal Medicine, Columbia-Presbyterian Medical Center, New York, NY, 1994-1997
  • Fellowship in Cardiology, New York Presbyterian Medical Center-Weill Cornell Medical School, New York, NY 1997-1999
  • Fellowship in Cardiac Electrophysiology, New York Presbyterian Medical Center-Weill Cornell Medical School, New York, NY 1999-2001

BOARD CERTIFICATION

  • American Board of Internal Medicine, 1997
  • American Board of Internal Medicine, Cardiovascular Disease, 2000
  • American Board of Internal Medicine, Clinical Cardiac Electrophysiology, 2001

AREAS OF CLINICAL EXPERTISE

  • Clinical cardiac electrophysiology
  • Radiofrequency ablation procedures for cardiac arrhythmias
  • Cardiac pacing and implantable cardioverter-defibrillator (ICD) therapy
  • Cardiac resynchronization therapy (CRT)

CURRENT RESEARCH INTERESTS

  • Clinical investigation into the mechanism, diagnosis, management, and prognosis of various arrhythmias, including atrial tachycardias, atrial fibrillation, ventricular tachycardias, and ventricular fibrillation
  • Efficacy of device-based therapies

SPECIAL ACCOMPLISHMENTS/RECENT PUBLICATIONS

  • BA cum laude, Harvard College, 1990
  • The Glorney-Raisbeck Fellowship in Cardiovascular Diseases, 2001
  • Iwai S, Lerman BB. Tachycardias. In: Rakel RE, Bope ET [eds]. Conn ’s Current Therapy 2010. Philadelphia : Saunders Elsevier, in press.
  • Markowitz SM, Lewen JM, Wiggenhorn CJ, Abraham WT, Stein KM, Iwai S, Lerman BB. Relationship of reverse anatomical remodeling and ventricular arrhythmias after cardiac resynchronization. J Cardiovasc Electrophysiol 2009;20(3):293-8.
  • Morin DP, Iwai S. Iatrogenic Twiddler’s Syndrome. J Interv Cardi Electrophysiol. DOI 10.1007/s10840-009-9408-5.
  • Iwai S, Lerman BB. Tachycardias. In: Rakel RE, Bope ET [eds]. Conn ’s Current Therapy 2009. Philadelphia : Saunders Elsevier, 2009:320-326
  • Patel A, Au E, Donegan D, Kim RJ, Lin FY, Stein KM, Markowitz SM, Iwai S, Weinsaft JW, Min JK, Lerman BB. Multidetector row computed tomography for identification of left atrial appendage filling defects in patients undergoing pulmonary vein isolation for treatment of atrial fibrillation: A comparison to transesophageal echocardiography. Heart Rhythm 2008;5:253-260.
  • Kenigsberg DN, Mirchandani S, Dover AN, Kowalski M, Wood MA, Shepard RK, Kalahasty G, Stein KM, Markowitz SM, Iwai S, Shah BK, Lerman BB, Mittal S, Ellenbogen KA. Sensing failure associated with the Medtronic Sprint Fidelis defibrillator lead. J Cardiovasc Electrophysiol 2008;19:270-74.
  • Cantillon DJ, Stein KM, Markowitz SM, Mittal S, Shah BK, Morin DP, Zacks ES, Janik M, Ageno S, Mauer AS, Lerman BB, Iwai S. Predictive value of microvolt T-wave alternans in patients with left ventricular dysfunction. J Am Coll Cardiol 2007;50:166-173.
  • Kim RJ, Iwai S, Markowitz SM, Shah BK, Stein KM, Lerman BB. Clinical and electrophysiologic spectrum of idiopathic ventricular outflow tract arrhythmias. J Am Coll Cardiol 2007; 49:2035-2043.
  • Markowitz SM, Nemirovsky D, Stein KM, Mittal S, Iwai S, Shah BK, Dobesh DP, Lerman BB. Adenosine-insensitive focal atrial tachycardia: Evidence for de novo microreentry in the human atrium. J Am Coll Cardiol 2007;49:1324-33.
  • Morin DP, Zacks ES, Janik M, Ageno S, Mauer AS, Cantillon DJ, Markowitz SM, Mittal S, Iwai S, Shah BK, Lerman BB. The effect of bundle branch block on microvolt T-wave alternans and electrophysiologic testing in patients with ischemic cardiomyopathy. Heart Rhythm 2007;4:904-912.
  • Zacks ES, Markowitz SM, Stein KM, Mittal S, Iwai S, Shah BK, Morin DP, Mauer A, Ageno S, Janik M, Lerman BB, Stein KM. Effect of oral β-blocker therapy on microvolt T-wave alternans and electrophysiology testing in patients with ischemic cardiomyopathy. Am Heart J 2007; 153:392-397.
  • Iwai S, Cantillon DJ, Kim RJ, Markowitz SM, Mittal S, Stein KM, Shah BK, Yarlagadda RK, Cheung JW, Tan VR, Lerman BB. Right and left ventricular outflow tract tachycardias: Evidence for a common electrophysiologic mechanism. J Cardiovasc Electrophysiol 2006;17:1052-1058.
  • Lu S, Gong Y, Iwai S, Stein KM, Lerman BB, Christini DJ. Structural barrier increases QT-peak dispersion in swine left ventricle in vivo. Conf Proc IEEE Eng Med Biol Soc 2006; 1:4039-42.
  • Cheung JW, Keating RJ, Stein KM, Markowitz SM, Iwai S, Shah BK, Lerman BB, Mittal S. Newly detected atrial fibrillation following dual chamber pacemaker implantation. J Cardiovasc Electrophysiol 2006;17:1323-1328.
  • Iwai S, Markowitz SM, Mittal S, Stein KM, Lerman BB. Electrophysiology of Cardiac Arrhythmias, In: Rosendorff C [ed]: Essentials of Cardiology: Principles and Practice, 2nd ed. Totowa: Humana Press, 2005:285-303.
  • Yarlagadda RK, Iwai S, Stein KM, Markowitz SM, Shah BK, Cheung JW, Tan V, Lerman BB, Mittal SM. Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract. Circulation 2005;112:1092-1097.
  • Cheung JW, Iwai S, Lerman BB, Mittal S. Shock-induced ventricular oversensing due to seal plug damage: A potential mechanism of inappropriate device therapies in implantable cardioverter-defibrillators. Heart Rhythm 2005;1371-1375.
  • Shah BK, Stein KM, Iwai S, Lerman BB. Pseudoblock and pseudoconduction across the cavotricuspid isthmus. Heart Rhythm 2005;2(7):750-753.
  • Stein KM, Devereux RB, Hahn RT, Markowitz SM, Mittal S, Iwai S, Lerman BB. Effect of transthoracic shocks on left ventricular function. Resuscitation 2005;66(3):309-315
  • Maybhate A, Hao SC, Iwai S, Lee JU, Guttigoli AB, Stein KM, Lerman BB, Christini DJ. Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model. IEEE Trans Biomed Eng 2005;52(7):1188-1194.
  • Guttigoli AB, Wilner BF, Stein KM, Markowitz SM, Iwai S, Shah BK, Yarlagadda RK, Lerman BB, Mittal S. Usefulness of prolonged QRS duration to identify high-risk ischemic cardiomyopathy patients with syncope and inducible ventricular tachycardia. Am J Cardiol 2005;95:391-394.
  • Lerman BB, Stein KM, Markowitz SM, Mittal S, Iwai S. Ventricular tachycardia in patients with structurally normal hearts. In: Zipes DP, Jalife J [eds]. Cardiac Electrophysiology: From cell to bedside. Philadelphia: Saunders, 2004:668-682.
  • Markowitz SM, Christini DJ, Stein KM, Mittal SM, Iwai S, Slotwiner DJ, Lerman BB. Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway. PACE 2004; 27:1638-1643.
  • Cheung JW, Stein KM, Markowitz SM, Iwai S, Guttigoli AB, Shah BK, Yarlagadda RK, Lerman BB, Mittal S. Significance of adenosine-induced atrioventricular block in patients with unexplained syncope. Heart Rhythm 2004;1(6):664-668.
  • Mittal S, Stein KM, Markowitz SM, Iwai S, Guttigoli A, Lerman BB. A single-stage adenosine tilt test in patients with unexplained syncope. J Cardiovasc Electrophysiol 2004; 2004;15:637-640.
  • Hao SC, Christini DJ, Stein KM, Jordan PN, Iwai S, Bramwell O, Markowitz SM, Mittal S, Lerman BB. Effect of beta-adrenergic blockade on dynamic electrical restitution in vivo. Am J Physiol Heart Circ Physiol; 2004:287(1):H390-394.
  • Mittal S, Stein KM, Markowitz SM, Iwai S, Guttigoli A, Lerman BB. An update on electrical cardioversion of atrial fibrillation. Card Electrophysiol Rev 2003;7:285-289.
  • Christini DJ, Stein KM, Hao SC, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Das MK, Lerman BB. Endocardial detection of repolarization alternans. IEEE 2003; 50(7):855-862.
  • Slotwiner DJ, Christini DJ, Stein KM, Markowitz SM, Mittal S, Iwai S, Das MK, Lerman BB. Muscle sympathetic nerve traffic during spontaneous versus adenosine-mediated termination of idiopathic right ventricular outflow tract tachycardia. Am J Cardiol 2003; 91:86-88.
  • Iwai S, Markowitz SM, Stein KM, Mittal S, Slotwiner DJ, Das MK, Cohen JD, Hao SC, Lerman BB. Response to adenosine differentiates focal from macroreentrant atrial tachycardia: Validation using three-dimensional electroanatomic mapping. Circulation 2002; 106:2793-2799.
  • Markowitz SM, Brodman RF, Stein KM, Mittal S, Slotwiner DJ, Iwai S, Das MK, Lerman BB. Lesional tachycardias related to mitral valve surgery. J Am Coll Cardiol 2002;39:1973-1983.
  • Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Lerman BB. Anatomic determinants of atrial arrhythmias: New insights from three-dimensional mapping. Chaos 2002;12:740-746.
  • Mittal S, Lomnitz DJ, Mirchandani S, Stein KM, Markowitz SM, Slotwiner DJ, Iwai S, Das MK, Lerman BB. Prognostic significance of nonsustained ventricular tachycardia after revascularization. J Cardiovasc Electrophysiol 2002;13:342-346.
  • Das MK, Stein KM, Canilang K, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Lerman BB. Significance of sustained monomorphic ventricular tachycardia induced with short coupling intervals in patients with ischemic cardiomyopathy. Am J Cardiol. 2002;89:987-990.
  • Mittal S, Hao SC, Iwai S, Stein KM, Markowitz SM, Slotwiner DJ, Lerman BB. Significance of inducible ventricular fibrillation in patients with coronary artery disease and unexplained syncope. J Am Coll Cardiol 2001;38(2):371-376.
  • Lerman BB, Ellenbogen KA, Kadish A, Platia E, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner M, Iwai S, Belardinelli L, Shreeniwas R, Wolff AA. Electrophysiologic effects of a novel selective adenosine A1 agonist (CVT-510) on atrioventricular nodal conduction in humans. J Cardiovasc Pharmacol Therapeut 2001;6(3):237-245.
  • Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Iwai S, Lerman BB. Complex AV-nodal dynamics during ventricular-triggered atrial pacing in humans. Am J Physiol Heart Circ Physiol 2001;281(2):H865-H872.
  • Stein KM, Mittal S, Slotwiner DJ, Markowitz SM, Iwai S, Lerman BB. Atrial tachycardia: Update. CEPR 2001;5(2/3):290-293.
  • Mittal S, Das MK, Stein KM, Markowitz SM, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Frequency of subacute resumption of isthmus conduction after ablation of atrial flutter. Am J Cardiol 2001: 87(9); 1113-1116.
  • Slotwiner DJ, Stein KM, Markowitz SM, Mittal S, Iwai S, Das M, Lerman BB. Emerging indications for cardiac pacing. Heart Disease 2001;3:224-230.
  • Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Nonlinear-dynamical arrhythmia control in humans. Proc Nat Acad Sci 2001;98(10):5827-5832.
  • Mittal SM, Stein KM, Markowitz SM, Slotwiner DJ, Iwai S, Das MK, Lerman BB. New advances in external cardioversion of atrial fibrillation. CVR&R 2001;22:411-415.
  • Iwai S, Lerman BB. Management of ventricular tachycardia in patients with clinically normal hearts. Current Cardiology Reports 2000: 2(6):515-521.
  • Mittal S, Iwai S, Stein KM, Markowitz SM, Slotwiner DJ, Lerman BB. Long-term outcome of patients with unexplained syncope treated with an electrophysiologic-guided approach in the implantable cardioverter-defibrillator era. J Am Coll Cardiol 1999; 34:1082-1089.

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